Bioprocess
Method notes, results and company news from Novasign.
BioprocessBioprocess DevelopmentMar 20, 2026De‑Risking Bioprocess Scale‑Up: Predictive Modeling for Reliable Fermentation and Cell Culture Manufacturing
Scaling a bioprocess from laboratory development to industrial manufacturing is one of the most critical, and risky steps in biotechnology. For contract development and manufacturing organizations (CDMOs), large pharmaceutical companies, industrial biotechnology producers, and emerging sectors such…
BioprocessBioprocess DevelopmentMar 20, 2026Autonomous Continuous Biomanufacturing: Closing the Gap Between Process Development and Production
Continuous biomanufacturing has long been considered one of the most promising approaches to increase productivity, reduce facility footprint, and enable more sustainable bioprocessing.
BioprocessBioprocess DevelopmentMar 20, 2026Next‑Generation Media Development: How Modeling Reduces Cost and Accelerates Bioprocess Optimization
Media composition is one of the least transparent elements in modern cell culture bioprocess development. Whether producing monoclonal antibodies, recombinant proteins, industrial enzymes, or cultivated food products, the composition of the cell culture or fermentation media directly determines…
BioprocessBioprocess DevelopmentApr 3, 2025Hybrid Modeling Meets Filtration: Optimizing UF and DF in Monoclonal Antibody Processing
Producing monoclonal antibodies often involves the challenge of balancing high protein concentrations with the risk of membrane fouling or poor recovery. Our innovative workflow captures detailed experimental data from a single experiment to characterize key variables like membrane behavior and…
BioprocessDec 13, 2021How to predict continuous ultrafiltration from batch experiments
Process development for continuous downstream processes is often performed in batch mode. The mode and process conditions, however, might not resemble the true continuous conditions. This is especially relevant for filtration processes where process knowledge such as membrane material, membrane…
BioprocessNov 16, 2021Advanced online sensors for monitoring and modeling of HEK 293 gene therapy processes
Emerging manufacturing technologies to treat diseases derived from monogenic disorders are of high importance for upcoming gene therapy approaches and by 2019, almost 150 unique clinical trials were reported. For such an in vitro and in vivo gene delivery, recombinant adeno-associated viruses…
BioprocessJun 22, 2020Intensified DoE and hybrid modeling accelerate upstream process characterization
Process characterization is necessary for the biopharmaceutical industry to guarantee a robust and uniform product quality output. Typically, two elements are applied to accomplish this task:
BioprocessMay 27, 2020Hybrid Models facilitate Scale-Up and Digital Twins for tangential flow filtration
The benefits of bioprocess modeling are well known:
BioprocessBiotechnologyAug 8, 2018Best talk @10th ÖGMBT Annual Meeting
From the 17th to the 20th of September, the 10th ÖGMBT Annual Meeting took place in Vienna. Over 450 participants including employees from large pharmaceutical companies, equipment vendors and students met at the campus of the University of Vienna. They presented the latest results in different…
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