Blog
Method notes, results and company news from Novasign.
BioprocessBioprocess DevelopmentMar 20, 2026Autonomous Continuous Biomanufacturing: Closing the Gap Between Process Development and Production
Continuous biomanufacturing has long been considered one of the most promising approaches to increase productivity, reduce facility footprint, and enable more sustainable bioprocessing.
BioprocessBioprocess DevelopmentMar 20, 2026Next‑Generation Media Development: How Modeling Reduces Cost and Accelerates Bioprocess Optimization
Media composition is one of the least transparent elements in modern cell culture bioprocess development. Whether producing monoclonal antibodies, recombinant proteins, industrial enzymes, or cultivated food products, the composition of the cell culture or fermentation media directly determines…
BioprocessBioprocess DevelopmentApr 3, 2025Hybrid Modeling Meets Filtration: Optimizing UF and DF in Monoclonal Antibody Processing
Producing monoclonal antibodies often involves the challenge of balancing high protein concentrations with the risk of membrane fouling or poor recovery. Our innovative workflow captures detailed experimental data from a single experiment to characterize key variables like membrane behavior and…
- Bioprocess DevelopmentDigital TwinDec 3, 2024
Viral Vector Manufacturing: 64% Fewer Experiments in Lytic Virus Production
In a recent project with our strategic partner bespark*bio, we combined our hybrid modeling with best-in-class bioprocessing expertise to maximize the efficiency of a Vero cell culture process producing a lytic virus. This approach to process optimization showed that instead of requiring 22…
- Mar 25, 2024
Empowering Insights and Innovations: Novasign's Path to Transforming Data into Action
At Novasign we've always been driven by the passion to innovate and optimize. Our journey from 2019 to 2023 is a testament to how small teams can achieve significant growth with the right strategies and relentless dedication. Back in 2019 and shortly after founding the company, we released our…
- Feb 9, 2022
Industry 4.0: Where are we, and how to accelerate the transition?
In order to move from industry 3.0 to 4.0 relevant process outputs (titer, product quality, certain impurities) have to be monitored and controlled in real-time. Process models provide the understanding of how input factors affect the outputs for every stage of the process in order to give…
- Dec 23, 2021
Reduced experimental burden in CHO process development across scale: hybrid modeling and iDoE
Process development in a QbD approach is accompanied by high experimental effort due to a design of experiments (DoE) approach at different scales, consuming large quantities of raw materials and time. For upstream process development of mammalian cell culture, this procedure is highly exhausting…
BioprocessDec 13, 2021How to predict continuous ultrafiltration from batch experiments
Process development for continuous downstream processes is often performed in batch mode. The mode and process conditions, however, might not resemble the true continuous conditions. This is especially relevant for filtration processes where process knowledge such as membrane material, membrane…
BioprocessNov 16, 2021Advanced online sensors for monitoring and modeling of HEK 293 gene therapy processes
Emerging manufacturing technologies to treat diseases derived from monogenic disorders are of high importance for upcoming gene therapy approaches and by 2019, almost 150 unique clinical trials were reported. For such an in vitro and in vivo gene delivery, recombinant adeno-associated viruses…
- Bioprocess DevelopmentBiotechnologyJul 28, 2021
Antleron and Novasign to join forces in ATMP Modeling
Advanced therapy medicinal products (ATMPs) are targeted therapies based on genes, cells, or tissues that deliver a therapeutic benefit to a patient-specific population and often treat rare diseases or improve upon existing treatments. The global ATMP market is expected to reach approximately 21.2…
Jun 28, 2021One Recipe for All
Who doesn’t like rice? My favorite is basmati rice and I have the perfect recipe for it: 1 cup of basmati and 1 ½ cups of cold water, boil for 12 min, let it rest for 10 min and done! My friends, however, prefer rice with peas which adds some uncertainty to my perfect recipe: The ratio between rice…
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