Bioprocess Development
Method notes, results and company news from Novasign.
BioprocessBioprocess DevelopmentMar 20, 2026De‑Risking Bioprocess Scale‑Up: Predictive Modeling for Reliable Fermentation and Cell Culture Manufacturing
Scaling a bioprocess from laboratory development to industrial manufacturing is one of the most critical, and risky steps in biotechnology. For contract development and manufacturing organizations (CDMOs), large pharmaceutical companies, industrial biotechnology producers, and emerging sectors such…
BioprocessBioprocess DevelopmentMar 20, 2026Autonomous Continuous Biomanufacturing: Closing the Gap Between Process Development and Production
Continuous biomanufacturing has long been considered one of the most promising approaches to increase productivity, reduce facility footprint, and enable more sustainable bioprocessing.
BioprocessBioprocess DevelopmentMar 20, 2026Next‑Generation Media Development: How Modeling Reduces Cost and Accelerates Bioprocess Optimization
Media composition is one of the least transparent elements in modern cell culture bioprocess development. Whether producing monoclonal antibodies, recombinant proteins, industrial enzymes, or cultivated food products, the composition of the cell culture or fermentation media directly determines…
BioprocessBioprocess DevelopmentApr 3, 2025Hybrid Modeling Meets Filtration: Optimizing UF and DF in Monoclonal Antibody Processing
Producing monoclonal antibodies often involves the challenge of balancing high protein concentrations with the risk of membrane fouling or poor recovery. Our innovative workflow captures detailed experimental data from a single experiment to characterize key variables like membrane behavior and…
- Bioprocess DevelopmentDigital TwinDec 3, 2024
Viral Vector Manufacturing: 64% Fewer Experiments in Lytic Virus Production
In a recent project with our strategic partner bespark*bio, we combined our hybrid modeling with best-in-class bioprocessing expertise to maximize the efficiency of a Vero cell culture process producing a lytic virus. This approach to process optimization showed that instead of requiring 22…
- Bioprocess DevelopmentBiotechnologyJul 28, 2021
Antleron and Novasign to join forces in ATMP Modeling
Advanced therapy medicinal products (ATMPs) are targeted therapies based on genes, cells, or tissues that deliver a therapeutic benefit to a patient-specific population and often treat rare diseases or improve upon existing treatments. The global ATMP market is expected to reach approximately 21.2…
Bioprocess DevelopmentOct 8, 2020The Future of Bioprocess Development - A Panel Discussion with Leading Experts
The emerging COVID-19 pandemic did oblige us to rearrange over habits and routines and presented bioprocess development with new challenges to master, i.e., current working procedures state-of-the-art techniques must be reshaped to put bioprocessing into a new light. Over the last months, many…
Bioprocess DevelopmentBiotechnologyApr 3, 2020COVID-19: An example of why we need robust and fast process development
The current worldwide situation regarding the COVID-19 pandemic has shown all of us how vulnerable our daily life can be. In the case of such an unpredicted event, everyone must make trade-offs, personal and economic. That is why in such situations it is of the highest priority to react fast and…
Bioprocess DevelopmentBiotechnologyMar 18, 2020COVID-19, Home Office and a New Toolbox Release
Due to the COVID-19 outbreak, the Austrian government decided to minimize unnecessary human interaction. These actions will reduce the number of new infections and flattens the curve, providing enough time for the health system to cope with these new unmet challenges. Hence, Novasign also followed…
Bioprocess DevelopmentBiotechnologyOct 18, 2019The Hybrid Modeling Summer School 2019
From the 25th to the 27th of September, Novasign co-hosted the 4th hybrid modeling summer school in Lisbon, Portugal. After a very detailed introduction to hybrid modeling by Prof. Rui Oliveira and Moritz von Stosch, the 41 participants were introduced to the pre-release Novasign hybrid modeling…
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